14.04.20De novo design of protein logic gates. Fundamental enzymology work. Chen et al. describe the design of logic gates that can regulate protein association. The gates were built from small, designed proteins that all have a similar structure but where one module can be designed to interact specifically with another module. Using monomers and covalently connected monomers as inputs and encoding specificity through designed hydrogen-bond networks allowed the construction of two-input or three-input gates based on competitive binding.
31.03.20 FRET community has a new advisory board, FRET community. Happy that Dr. Marcelle König , a senior scientist in PicoQuant was elected.
29.01.20 Beautiful biophysical study by Andrea Soranno and colleagues, showing how aromatic residues in prion-like protein domains determine liquid-liquid phase behavior in cells. As part of a multipronged experimental and computational strategy to unravel the phase behavior of the heterogeneous nuclear ribonucleoprotein A1, they performed FCS measurements with PicoQuant's MicroTime 200 microscope to probe the mobility of proteins inside and outside of droplets. Valence and patterning of aromatic residues determine the phase behavior of prion-like domains
04.09.19FRET.community website is online. The FRET community serves as a hub for joint scientific efforts in the field of Förster resonance energy. Note also that recently smFRET.org by T.Ha group was also released.