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start [2019/10/24 12:53] – sisamakis | start [2020/04/14 11:25] – sisamakis |
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===== News from the community===== | ===== News from the community===== |
24.10.19 New publication [[https://www.nature.com/articles/s41467-019-12304-4|DNA mechanotechnology reveals that integrin receptors apply pN forces in podosomes on fluid substrates]] introducing the approach of **Molecular Tension-Fluorescence Lifetime Imaging Microscopy (MT-FLIM)** | * **14.04.20** [[https://analyticalscience.wiley.com/do/10.1002/was.00050003/full/bioimagedataanalysis.pdf|Bioimage Data Analysis.]] New Expanded version of a nice open-source introduction. \\ \\ |
| * **14.04.20** [[https://science.sciencemag.org/content/368/6486/78|De novo design of protein logic gates.]] Fundamendal enzymology work. Chen et al. describe the design of logic gates that can regulate protein association. The gates were built from small, designed proteins that all have a similar structure but where one module can be designed to interact specifically with another module. Using monomers and covalently connected monomers as inputs and encoding specificity through designed hydrogen-bond networks allowed the construction of two-input or three-input gates based on competitive binding. \\ \\ |
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